![]() ![]() ![]() At a July news conference organized by the International AIDS Society, Dr. In Italy, researchers found that almost 90% of COVID patients exhibited symptoms after apparently recovering from the coronavirus. Rae’s is a situation that many COVID survivors are familiar with - having seemingly recovered from COVID, only to have recurring symptoms months later. She fears she’ll “just be stuck with this forever and hear, ‘Well, you probably had COVID in early March - good luck.’” “I’m pretty sure that will come back negative,” she says. Now, she’s seeing doctors about testing to rule out any autoimmune conditions that could be behind her new symptoms. She’s had a fever every day since, and while she’s tested negative for both COVID and antibodies after her symptoms re-emerged, her doctors still label her a presumed COVID case. As June progressed, Rae developed rashes over her face and neck, along with a daily fever - a symptom Rae hadn’t experienced since the first week of April. Each time she tried, she became so exhausted, she couldn’t get out of bed for days at a time and her temperature would rise again. Then, throughout May and early June, Rae would try to do some yoga, or walk for a half hour - a light version of her pre-COVID workouts. She was sick for around 28 days, and though she still had some lingering fatigue, she and her doctor basically thought she’d recovered. Since coronavirus testing wasn't widespread in March, her case was presumed positive. The 32-year old, Washington, D.C.-based attorney started running a daily fever and had shortness of breath so intense that it landed her in the emergency room twice. Here we highlight studies that contribute to our understanding of this evolving field.Rae* thinks she contracted coronavirus the first week of March while at a work conference. Nevertheless, important insights about these and other aspects of post-COVID conditions continue to emerge and are shaping clinical decision-making, public health policy and research initiatives. Given these limitations in individual studies, it is similarly challenging to draw definitive broad conclusions about the pathogenesis, epidemiology, prevention and management of post-COVID conditions based on data across different studies. This includes difficulty identifying patients with post-COVID conditions in a consistent and systematic fashion and defining appropriate “control” populations for comparison. A separate definition may be applicable for children.” Key LiteratureĪs noted previously, all-encompassing standardized definitions of post-COVID conditions remain elusive, which means studies of patients at risk for or experiencing post-COVID symptoms have important methodologic and analytic limitations. Symptoms may also fluctuate or relapse over time. Symptoms may be new onset, following initial recovery from an acute COVID-19 episode, or persist from the initial illness. Common symptoms include fatigue, shortness of breath, cognitive dysfunction but also others which generally have an impact on everyday functioning. ![]() “Post COVID-19 condition occurs in individuals with a history of probable or confirmed SARS-CoV-2 infection, usually 3 months from the onset of COVID-19 with symptoms that last for at least 2 months and cannot be explained by an alternative diagnosis. In 2021, the World Health Organization published a working clinical case definition of post-COVID conditions that was developed by Delphi consensus (an iterative survey of experts, patients and other stakeholders designed to create a consensus definition): Centers for Disease Control and Prevention uses the umbrella term “ post-COVID conditions” to capture health problems that occur 4 or more weeks after acute COVID-19 infection.īecause of the wide variety of symptoms that may be encompassed by post-COVID conditions, and the lack of a definitive diagnostic test, standardized case definitions have been challenging to develop. These symptoms are referred to by many different names, including “long COVID,” “long-haul COVID,” “chronic COVID,” “post-COVID syndrome” and “post-acute COVID-19 syndrome,” as well as the research term “post-acute sequelae of SARS-CoV-2 infection (PASC).” The U.S. Some patients experience new, recurring or ongoing symptoms related to COVID-19 several weeks after the acute phase of infection ( Nalbandian, March 2021 Hope, June 2022). Some sections may reflect more recent updates. This page undergoes regular review and was last comprehensively reviewed on August 16, 2022. ![]()
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